Thank you for looking to add a Zanbellia puppy to your family. Our puppies are raised indoors, in a busy house hold with children of varying ages. Our puppies are from health tested parents and well adjusted with thanks to follow Puppy Culture Practices and ensuring our puppy receive a lot of socialisation and interaction. We also have indoors cats ( Siamese and Sphynx) so they are used to other indoor pets. Currently tests are sent overseas to UC Davis Lab and can only test for FEH, Glaucoma, PRA and PLL. Please see parents pages for DNA results. Please always ensure you ask to see copies of tests results.
Below is some information on which tests will be done on our adults to ensure we comply with Dogs Victoria Code of Practices which brings us inline with the Victoria State laws.
We recommend pet insurance for your new family member. Puppies will come with 6 weeks free insurance provided by Petplan to registered breeder.
Please visit UC Davis for more information on there test. https://www.vgl.ucdavis.edu/services/italiangreyhound.php
Familial Enamel Hypoplasia of Italian Greyhounds
Autosomal recessive amelogenesis imperfecta (ARAI) is an inherited genetic disorder of tooth enamel that occurs in Italian Greyhounds. It is commonly known to breeders as Familial Enamel Hypoplasia (FEH). It is characterized by enamel pitting and tooth discoloration; often teeth are unusually small, pointed and prone to increasing gaps between teeth with age. There appears to be no association of FEH with periodontitis. Dr. Niels Pedersen and his research group at the School of Veterinary Medicine, University of California-Davis identified the mutation associated with FEH in Italian Greyhounds. It is estimated that 14% of Italian Greyhounds are affected with FEH and 30% are carriers.
Italian Greyhound with normal teeth. Teeth are larger, not pointed; enamel is smooth, not discolored. Gaps between teeth are narrower.
Italian Greyhound with FEH. The enamel surfaces are roughened, with blochy discoloration. Cavities are uncommon, but this dog has cavities at tips of upper and lower canines.
The Veterinary Genetics Laboratory offers a test for FEH to assist owners and breeders in identifying affected and carrier dogs. The test uses DNA collected from buccal (cheek) swabs, thus avoiding blood sample collection. Breeders can use results from the test as a tool for selection of mating pairs to avoid producing affected dogs.
Susceptibility to Primary Closed Angle Glaucoma in Italian Greyhounds
In Italian Greyhounds, primary closed angle glaucoma (PCAG)is a hereditary disease that results from a rapid build-up of pressure in the eye, which causes loss of optic nerve function and retinal ganglion cell loss. The onset of this condition is sudden, painful and if left untreated will lead to blindness. The average age of dogs at diagnosis is 3.9 years (range 0.5 to 6 years). Research by Dr. Niels Pedersen and Hongwei Liu at UC Davis identified 2 linked mutations that are present in 75% of Italian Greyhounds with primary closed angle glaucoma.
Susceptibility to PRA in Italian Greyhounds
Progressive retinal atrophy (PRA) is a genetic disease characterized by progressive degeneration of the photoreceptors in the retina that leads to blindness. There is no treatment for PRA. The incidence of PRA in Italian Greyhounds is 2-4% and it is usually diagnosed at 1 to 14 years of age (6.5 years average). Recent discoveries by UC Davis canine researchers Dr. Niels Pedersen and Hongwei Liu identified mutations in 5 loci that are associated with susceptibility to 90% of the PRA in Italian Greyhounds. This form of PRA, designated as PRA-IG1, can be subdivided into 3 subtypes (PRA-IG1a, 1b, and 1c) based on risk genotypes. PRA-IG1a is associated with allele (a) at the major locus that is solely responsible for blindness when in a homozygous state (aa). PRA-IG1b occurs when this allele is in the heterozygous state (Aa) and associated with alleles b and c. PRA-IG1c involves alleles a, d and e loci in various combinations. PRA-IG1a comprises 42% of PRA cases in the breed, PRA-IG1b 29%, and PRA-IG1c 20%.
Primary Lens Luxation (PLL)
is a painful inherited eye disorder where the lens of the eye moves from its normal position causing inflammation and glaucoma. PLL results from a single base change mutation in the gene ADAMST17. If untreated, the condition can rapidly lead to blindness. The disease is inherited in an autosomal recessive fashion thus both sexes are equally affected. PLL appears spontaneously, typically between 3-8 years, although both eyes are not necessarily affected at the same time. Watery, red, teary eyes may indicate that lens luxation has occurred and veterinary intervention is required. Dogs with only one copy of the disease mutation most frequently show no sign of the disease but can, on occasion, develop PLL.
Epilepsy: Can be found within the breed, at the moment there is no DNA test for this, as Epilepsy usually shows before 2 years of age we like try and ensure our girls are older than this to make sure they don't present with it. To date we haven't had any issues with our lines and they have come from well established breeders, so while I can't say I won't ever have it within my kennel, I am trying my very best to not.
Heart Testing - During 2019 all of our dogs over 1 year of age have undergone Echocardiographs due to sometimes heart murmurs being found within the breed. This will be undertaken by a Specialist at University of Werribee Vet Clinic
Eye Testing: During 2020 As well as the DNA for PRA we will also be working with Melbourne Eye Clinic for Animals and having our dogs OFA tested for PRA as well. This way we can make doubly sure all current tests are working, it may seem like we are repeating both tests but we want to ensure our dogs are the healthiest they can be.
Patellas: A lot comes into play when there is patella issues within dogs. A lot comes down to diet and exercise but most certainly can also be genetic. To ensure the genetic link is at its least we are working on having all dogs not just the physical exam that they currently under go but also Xraying and reporting on them.
Genetic Diversity: UC Davis has added genetic diversity to there panel of testing. This allows us to see which genes make up a dog and try and not double up on as many to reduce the likelihood of autoimmune diseases. Whilst we dont have a huge gene pool in Australia we hope this will give us knowledge to stop a bottleneck affect. The diversity between siblings can be quite remarkable/
Zanbellia want to ensure we are doing the very best we can for the breed by breeding from the healthiest dogs we can. We understand that this doesn't 100% guarantee everything but it shows we have done the very best to prevent it. We wish you all the success in adding this wonderful breed to your family. They are brilliant dogs and I certainly couldn't live without them. All reports will be added to pages as they become available.